by. Ana Sirley Calderon Flores. on 11 November Comments (0). Please log in to add your comment. Report abuse. Transcript of ANEMIA MACROCITICA. Megaloblastosis can be associated with severe anemia and pancytopenia, gastrointestinal dysfunction and glossitis, personality changes. Macrocytosis without anemia may be a normal variant and is only noted as a result of repeated peripheral RBC indices in the absence of any known or existing.

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Megaloblastic anemia has a rather slow onset, especially when compared andmia that of other macroocitica. In some cases, a bone marrow examination may be necessary. Macrocytosis is a relatively common finding in the era of automated blood cell counters, with prevalence estimates ranging from 1. The hydroxylated form of cobalamin plays an important role in the metabolism of homocysteine and MMA.

Publicar un comentario Este es un blog dirigido a profesionales sanitarios. In patients with elevated MCV values, laboratory tests for vitamin B12 and folate deficiencies are routinely ordered by physicians, although these tests are limited by their low sensitivity and specificity.

A full hematologic response should occur within 8 weeks. Additionally, a careful review of the peripheral blood smear noting the morphology of the RBCs, as well as the other cellular elements and features on the smear, can provide important clues as to the etiology of the anemia.

However, its identification can provide important information regarding the presence of an underlying disease state.

Storage of blood and the mean corpuscular volume. Clinical spectrum and diagnosis of folate deficiency.


Megaloblastic Anemia and Other Causes of Macrocytosis

Inflamm Bowel Dis ; 9: This article has been corrected. Determining the underlying cause of the macrocytosis can be particularly challenging when thalassemia trait or iron deficiency or other macrocitlca deficiencies coexist with a vitamin B12 or folate deficiency.

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Megaloblastic anemia – Wikipedia

However, these tests are expensive and not always available to the practicing clinician. Overview – eMedicine Hematology”. These large polychromatophilic erythrocytes noted on the peripheral smear represent reticulocytes, immature RBCs that are larger than mature RBCs, and are indicative of increased erythropoiesis or RBC production and, if present in increased number, can raise the MCV. Robinson AR, Mladenovic J. Iron-deficiency anemia Plummer—Vinson syndrome Macro-: Find articles by Joseph J.

ANEMIA MACROCITICA by Ana Sirley Calderon Flores on Prezi

This abnormality is usually recognized by the automated blood cell counter and confirmed on review of the peripheral blood smear. N Engl J Med ; Until one is identified, it is recommended that when initial vitamin B12 values are low i.

Clin Chem Lab Med ; Lo felicito por la riqueza de informacion, me ayudado mucho en una exposicion fisiopatologica del tema. The term macrocytosis refers to a blood condition in which red blood cells RBC are larger than normal.

Postgrad Med J ; Retrieved October 23, Peripheral blood smear madrocitica hypersegmented neutrophils, characteristic of megaloblastic anemia. Archived from the original on 30 November Hereditary spherocytosis Minkowski—Chauffard syndrome Hereditary elliptocytosis Southeast Asian ovalocytosis Hereditary stomatocytosis. National Center for Biotechnology InformationU.

This time-honored method remains an acceptable form of treatment for all causes of vitamin B12 deficiency, particularly when cognitive impairment or neurologic disease is present. Metotrexato, Pirimetamina, Triamtirene, Pentamidina, Trimetoprima. Hoffbrand V, Provan D. Because of the limitations of measuring serum folate, RBC folate levels have been advocated as a more reliable source of measuring tissue stores of folate.


The marrow is hypercellular with all forms of the myeloid cell line being increased and erythroid elements being dominant on the marrow aspirate smear preparations. It is imperative that a hematologist or hematopathologist examine the xnemia in order to appreciate these important, subtle, hematopoietic abnormalities. Drugs Alcoholism Reticulocytosis Nonalcoholic and alcoholic liver disease Hypothyroidism Vitamin B12 deficiency Folate deficiency Multiple myeloma Myelodysplastic syndromes Aplastic anemia Acute leukemia.

Megaloblastic anemia

The level of methylmalonic acid is not elevated in folic acid deficiency. Macrocytosis due to vitamin B12 or folate deficiency is a direct result of ineffective or dysplastic erythropoiesis. Clin Lab Med ; macrocigica Los reflejos pueden estar atenuados o exaltados.

Macrocytosis without anemia may be a normal variant and is only noted as a result of repeated peripheral RBC indices in the absence of any known or existing clinical problems. Clin Ther ; A reticulocyte count should be obtained if there is evidence of hemolysis on the peripheral smear, i.

This ineffective erythropoiesis is accompanied by anemiz hemolysis causing an elevated lactate dehydrogenase and indirect bilirubin in the serum. Oak Avenue, Marshfield, Wisconsin Los signos de Romberg y Babinski pueden ser positivos.