La oxihemoglobina es un compuesto formado por la unión de la hemoglobina al efecto Bohr Union del oxigeno al hierro de la hemoglobina: El quinto orbital. 2 Estructura.. 3 Oxihemoglobina.. 4 Efectores alostericos: 2,3- Bisfosfoglicerato.. 5 Efecto Bohr.. 6 Importancia biomédica.. 7 Tipos de hemoglobina. Interacciona coas subunidades beta da hemoglobina desoxixenada facendo diminuír O efecto Bohr é outra vía útil para resolver o problema da afinidade da .
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The Haldane effect is a property of hemoglobin first described by John Scott Haldane. Oxygenation of blood in the lungs displaces carbon dioxide from hemoglobin which increases the removal of carbon dioxide.
This property is the Haldane effect. Conversely, oxygenated blood has a reduced affinity for carbon dioxide.
Haldane effect – Wikipedia
Carbon dioxide can bind to amino groups, creating carbamino compounds. Amino groups are available for binding at the N-terminals and at side-chains of arginine and lysine residues in haemoglobin.
Carbaminohaemoglobin is the major contributor to the Haldane effect.
Histidine residues in hemoglobin can accept protons and act as buffers. Deoxygenated hemoglobin is a better proton acceptor than the oxygenated form.
In red blood cells, the enzyme carbonic anhydrase catalyzes the conversion of dissolved carbon dioxide to carbonic acidwhich rapidly dissociates to bicarbonate and a free proton: The majority of carbon dioxide in the blood is in the form of bicarbonate. Only a very small amount is actually dissolved as efeco dioxide, and the remaining amount of carbon dioxide is bound to hemoglobin.
In addition to enhancing removal of hemoglovina dioxide from oxygen-consuming tissues, the Haldane effect promotes dissociation of carbon dioxide from hemoglobin in the presence of oxygen.
In the oxygen-rich capillaries of the lung, this property causes the displacement of carbon dioxide to plasma as low-oxygen blood enters the alveolus and is vital for alveolar gas exchange. The general equation for the Haldane Effect is: In patients with lung disease, lungs may not be able to increase alveolar ventilation in the face of increased amounts of dissolved CO 2. This partially explains the observation that some patients with emphysema might have an increase in P a CO 2 partial pressure of arterial dissolved carbon dioxide following administration of supplemental oxygen even if content of CO 2 stays equal.
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June Learn how and when to remove this template message. Nunn’s Applied Respiratory Physiology 5th ed. Scandinavian Journal of Clinical and Laboratory Investigation.
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