IJCRI – International Journal of Case Reports and Images, Vol. 4 No. 11, November ISSN – [] IJCRI ;4(9)– Komda PP KIPI Komite Daerah Pengkajian dan Penanggulangan Kejadian Ikutan Pasca Imunisasi. Komnas PP KIPI Komite Nasional. medik kejadian ikutan pasca imunisasi bagi petugas kesehatan. 4th ed. Jakarta: KN PP KIPI; Akib AAP. Kejadian ikutan : Trihono.

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Published on Jan View 6 Download 2. Gout is the most common inflammatory arthropathy. It has been reported to affect 2. In this report, we presented an uncommon case of tophaceous gout of the knee presenting as a soft tissue mass. A year-old male patient with knee pain and localized progressive swelling increasing in time on the medial side of the proximal tibia was seen in our clinic. He did not have any rheumatologic disease known previously except gout arthritis.

Excisional biopsy was performed by preserving medial collateral ligament and histopathologic investigations were done next. A tophaceous gouty deposit was identified by low-power photomicrograph. A bluish amorphous material was seen surrounded by bundles of dense collagenized tissue and chronic inflammatory cells. Photomicrograph of another section has been stained by de Galanthas method for demonstration of monosodium urate crystals. Especially in patients with extra-articular or subcutaneus mass, tophaceous gout must be considered as differential diagnosis.

Tophi gout around the knee joint: An unusual presentation with a soft tissue mass. International Journal of Case Reports and Images ;4 Initially, he was examined by a physiotherapist and treated conservatively. After that he had come to our polyclinic with increased complaints.

Physical examination of the knee revealed well circumscribed, solid, measuring approximately 5×5 cm, non-mobile soft tissue mass. The patient has no limitation of the joint motion. The mass was on the proximal tibial metaphysial region, it was located subcutaneously and vicinity of bone. It was hard and fixed with smooth border by palpation.

The blood uric acid levels were in normal range. His past history revealed that the patient had been using colchicine for 15 years. A year before, he had traffic accident and had injured his right knee with no fracture. Calcific myonecrosis, pigmented villonodular synovitis, calcinosis, gout tophus and especially synovial sarcoma were considered as differential diagnosis. An excisional biopsy was planned. A longitudinal incision was made along the length of anteromedial side of proximal tibia.

Tumor mass was completely excised with insertion of medial collateral ligament. There was an eroded area underlying the mass on proximal medial tibia but without a lytic area. The tumor and the eroded area of the bone extirpated via a curved osteotome. The remaining proximal part of medial collateral ligament was reattached to the tibia by suturing using fiber wire imjnisasi previously prepared drill holes.


Histopathologic investigations were done next. A bluish amorphous material is seen surrounded by bundles of dense collagenized tissue and chronic inflammatory cells. The field examined by polarized light. The birefringence of the crystalline material was evident. Surrounding the amorphous crystalline deposit was a thin layer of mononuclear and giant cells. Photomicrograph of another section had been stained by de Galanthas method for demonstration of monosodium urate crystals Figure 2.

The rate of kejadain of gross tophaceous deposits is a consequence of the gout disease and the degree of hyperuricemia [6]. Patients might have such complaints; warmth, pain, swelling and extreme tenderness imunissasi a joint, limited motion in the affected joint which mimics septic arthritis symptoms [4]. Chronic tophaceous gout classically kejadixn after 10 years or more of recurrent polyarticular gout.

However, demonstrating tophi as the initial clinical presentation of gout is very rare [8]. Subcutaneous tophi generally occurs as a late clinical outcome and typically located in the peripheral joints of the hand or foot [10].


But subcutaneous tophaceous deposits of monosodium urate, in the absence of arthritis, may occasionally occur as the initial manifestation of gout. InIglesias et al. They had reviewed literature and found out 28 similar cases that had subcutaneous nodules without any articular complaint and termed this entity of the disease as the gout nodulosis.

Thus, it seems that tophi deposition may occur early, even in previously unaffected joints. An earlier correct diagnosis of tophaceous gout could be made incidentally during an arthroscopy or with the help of the radiologist [2, 6]. Tophi are rarely observed in patients without a prior history of gouty arthritis. We describe a patient whose Figure 1: Anteroposterior diameter 54 mm, craniocaudal length 48 mm, mediolateral diameter: Macroscopic and microscopic histological images of the mass.

If hyperuricemia persists for a long time, tophaceous deposits may be found in the subcutaneous tissues and the various joints, particularly the first metatarsophalangeal joint, the hand, wrist, or elbow [25]. Tophaceous deposition has been reported in various locations such as finger pads, Sacroiliac joint, carpal tunnel, ankle, shoulder, dorsum of the feet, multiple IJCRI International Journal of Case Reports and Images, Vol. As far as we know although intra-articular gouty deposits in the knee are common, subcutaneous nodules are rare [10].

Our patient did not have a history of acute gouty arthritis tophi elsewhere. Tophaceous gout without arthritis might be more common than previously recognized.

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For diagnosis of gouty deposits in and around the knee plain radiographs, MRI and computed tomography CT [5, 9, 17] scan can be used. The plain radiographs show asymmetrical soft tissue swelling, calcication and bone erosion [17]. These plain radiographic features generally are normal in early and even chronic gout patients with intra-articular deposits and bone erosions [6]. Tophaceous deposits present as masses on MRI scan with low to intermediate signal intensity on both T1- and T2-weighted images and a characteristic enhancement pattern following intravenous Gd administration.


These features relate primarily to internal calcifications, which are most evident on CT scans. Magnetic resonance imaging scan including Gd administration supplemented, in some cases, with CT scan allows accurate diagnosis of intra-articular tophaceous deposits [9].

Computed tomography scan discloses round and oval opacities in the tophi [17]. Gout is marked by transient attacks kejarian acute arthritis initiated by crystallization of jkutan within and about the joints []. Although peri- and intra-articular structures are involved in the knee visible subcutaneus lesions are extremely unusual [22].

The soft tissue lesions of the tophaceous gout can have similar appearances to calcinosis of chronic renal failure, synovial sarcoma, osteosarcoma, calcific myonecrosis, myositis ossificans and tumoral calcinosis, so medical history of the patient is essential to evaluate the origin of these lesions and to detect the possible etiology. Synovial sarcomas are most commonly seen in large joints.

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They originate from bursal and tendineus structures [23]. These were, most frequently, incorrectly diagnosed as bursitis, tendinitis, synovitis or hematoma. In tumoral mass there may be mineralization and also this calcification can be also seen on X-ray. In some cases the underlying bone is affected and erosions can be seen [24].

Due to this features, in our case there was a diagnostic dilemma between synovial sarcoma and gout tophi. Computed tomography scan should be applied preoperatively to detect bone erosions that could help to plan the surgery.

Epidemiology, disease progression, treatment and disease burden. Curr Med Res Opin Dec;26 Intraarticular tophi in a joint without previous gouty attack. J Rheumatol Aug;30 8: Tophaceous deposition in the finger pads pazca gouty arthritis. Arch Intern Med Aug; 8: Concomitant septic and gouty arthritis–an analysis of 30 cases.

Rheumatology Oxford Sep;42 9: Computed tomography of the knee joint as an indicator of intraarticular tophi in gout. Arthritis Rheum Aug;39 8: A radiological reevaluation of gout: A study of 2, patients. Carpal tunnel syndrome caused ikuan tophaceous gout: CT and MR imaging in 20 patients. Tophi as first manifestation of gout. Intra-articular gouty tophi of the knee: CT and MR imaging in 12 patients. Skeletal Radiol Feb;28 2: Limited knee joint range of motion due to invisible gouty tophi.

Rheumatology Oxford Feb;43 2: Tophaceous gout of the spine: Clin Radiol Oct;57 Tophaceous gout of the spine in a patient with no peripheral tophi: Case report and review of the literature.

Arthritis Rheum Nov;28 Lower back pain caused by tophaceous gout of the spine. Neurology Aug 4;73 5: